Descrição
- This extensively updated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics–an area that has made significant advances since publication of the first edition. The opening section presents the principles of cancer genetics and introduces the basic concepts and mechanisms of tumorigenesis and inherited predisposition to cancer. The second part of the book provides information, on a systems basis, on the incidence, significance and management of predisposition to individual cancers. The final section deals with specific inherited cancer syndromes, giving practical guidance on clinical investigation, screening and management of affected patients and relatives at risk. The authors also provide up-to-date details of the genetic mapping of inherited cancer syndromes and the molecular genetic changes in individual cancers. Finally, an appendix provides a helpful revision guide to the fundamental principles of genetics. This practical and clear account will benefit clinicians and research workers in oncology, genetics, surgery and general medicine. – Contents.: Foreword; Preface; Part I. General Principles of Cancer Genetics: Chromosomes and cancer; Molecular genetics of cancer; Genetic predisposition to cancer; Ethical issues in human cancer genetics; Part II. Genetics of Human Cancer by Site of Origin: Central nervous system; Eye; Cardiorespiratory system and thorax; endocrine system; Gastro-intestinal system; Reproductive system; Urinary system; Haematological and lymphoid neoplasia; Musculoskeletal system; Skin tumours and inherited disorders predisposing to skin tumours; Inherited conditions predisposing to dermatological malignancy; Part III. Inherited Cancer-Predisposing Syndromes: Appendix; Index.
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- Paperback : 350 pages
- ISBN-10 : 0521649617
- ISBN-13 : 9780521649612
- Obs.: Livro sem uso, com paginas amareladas e um pouco sujas pelo tempo – capa, contracapa, bordas e paginas integras. sem marcas, grifos, marcações ou qualquer tipo de detalhe que possa interferir na leitura ou pesquisa – Conteudo perfeito
