- In recent years, there has been an alarming increase in environmental by-products that may be harmful to ovarian function. Along with this dangerous situation, the modern trend toward delaying motherhood poses immediate concerns regarding the long-term impact of environmental risks on human fertility. The uncertainty of our reproductive future intensifies the need for a single reference that investigates the chemicals with the potential to jeopardize fertility. The only known text that deals specifically with toxicity in the ovary, Ovarian Toxicology updates our current understanding of the effects of environmental chemicals on ovarian function. This new title in the Target Organ Toxicology Series presents an overview of ovarian physiology, examines the key ovarian target sites, assesses the effects of specific chemicals demonstrated in animal studies, and evaluates related human epidemiological data. Featuring the most complete review available of ovarian metabolism of xenobiotics, chapters also discuss ovarian cancer and modeling and testing for ovarian effects. With its clear handling of data and issues that are crucial to fertility studies, this comprehensive exploration of ovarian toxicology identifies the realistic risks for damage that our environment has the potential to inflict. It will be welcomed by toxicologists and ovarian physiologists, those in the pharmaceutical industries and regulatory agencies, and postgraduate researchers striving to safeguard women’s fertility and ensure our reproductive future. CONTENTS.: Introduction, Patricia B. Hoyer, Ph.D. Ovarian Physiology, Diane E. Suter, Ph.D. Ovarian Toxicity in Small Pre-antral Follicles, Patricia B. Hoyer, Ph.D. Ovarian Toxicity Caused by Pesticides, Jodi A. Flaws, Ph.D. Ovarian Toxicity Caused by Endocrine Disruptors, Paul Terranova, Ph.D. Ovarian Toxicity Caused by Phthalates, Barbara J. Davis , Ph.D. Disruption of Neuroendocrine Regulation of Ovulation, Ralph Cooper, Ph.D. Disposition and Ovarian Metabolism of Environmental Chemicals, I. Glenn Sipes, Ph.D. Transplacental Induction of Ovarian Toxicity, Jennifer Marcinkiewicz, Ph.D. Chemoresistance in Ovarian Cancer, Benjamin Tsang , Ph.D. Epidemiological Evidence for Environmental Chemicals in Ovarian Cancer, Kathryn Coe, Ph.D. Assessment of Ovarian Toxicity, Testing, Methodological End Points, In Vitro/Ex Vivo Testing, Jerome M. Goldman, Ph.D.
- Hardcover : 240 pages
- ISBN-10 : 0415287952
- ISBN-13 : 9780521780230
- Obs.: Livro sem uso, com paginas amareladas e um pouco sujas pelo tempo – capa, contracapa, bordas e paginas integras. sem marcas, grifos, marcações ou qualquer tipo de detalhe que possa interferir na leitura ou pesquisa – Conteudo perfeito