MECHANICS OF INHALED PHARMACEUTICAL AEROSOLS

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Descrição

  1. Contents
  2. Preface
  3. Acknowledgments
  4. Chapter 1. Introduction
  5. Chapter 2. Particle Size Distributions
  6. 2.1 Frequency and count distributions
  7. 2.2 Mass and volume distributions
  8. 2.3 Cumulative mass and volume distributions
  9. 2.4 Other distribution functions
  10. 2.5 Summary of mean and median aerosol particle sizes
  11. Chapter 3. Motion of a Single Aerosol Particle in a Fluid
  12. 3.1 Drag force
  13. 3.2 Settling velocity
  14. 3.3 Drag force on very small particles
  15. 3.4 Brownian diffusion
  16. 3.5 Motion of particles relative to the fluid due to particle inertia
  17. 3.6 Similarity of particle motion: the concept of aerodynamic diameter
  18. 3.7 Effect of induced electrical charge
  19. 3.8 Space charge
  20. 3.9 Effect of high humidity on electrostatic charge
  21. Chapter 4. Particle Size Changes due to Evaporation or Condensation
  22. 4.1 Introduction
  23. 4.2 Water vapor concentration at an air–water interface
  24. 4.3 Effect of dissolved molecules on water vapor concentration at an air–water interface
  25. 4.4 Assumptions needed to develop simplified hygroscopic theory
  26. 4.5 Simplified theory of hygroscopic size changes for a single droplet: mass transfer rate
  27. 4.6 Simplified theory of hygroscopic size changes for a single droplet: heat transfer rate
  28. 4.7 Simplified theory of droplet growth or evaporation of a single droplet whose temperature is cons
  29. 4.8 Use of the constant temperature equation for variable temperature conditions and a single drople
  30. 4.9 Modifications to simplified theory for multiple droplets: two-way coupled effects
  31. 4.10 When are hygrosopic size changes negligible?
  32. 4.11 Effect of aerodynamic pressure and temperature changes on hygroscopic effects
  33. 4.12 Corrections to simplified theory for small droplets
  34. 4.13 Corrections to account for Stefan flow
  35. 4.14 Exact solution for Stefan flow
  36. 4.15 When can Stefan flow be neglected?
  37. Chapter 5. Introduction to the Respiratory Tract
  38. 5.1 Basic aspects of respiratory tract geometry
  39. 5.2 Breath volumes and flow rates
  40. Chapter 6. Fluid Dynamics in the Respiratory Tract
  41. 6.1 Incompressibility
  42. 6.2 Nondimensional analysis of the fluid equations
  43. 6.3 Secondary flow patterns
  44. 6.4 Reduction of turbulence by particle motion
  45. 6.5 Temperature and humidity in the respiratory tract
  46. 6.6 Interaction of air and mucus fluid motion
  47. Chapter 7. Particle Deposition in the Respiratory Tract
  48. 7.1 Sedimentation of particles in inclined circular tubes
  49. 7.2 Sedimentation in alveolated ducts
  50. 7.3 Deposition by impaction in the lung
  51. 7.4 Deposition in cylindrical tubes due to Brownian diffusion
  52. 7.5 Simultaneous sedimentation, impaction and diffusion
  53. 7.6 Deposition in the mouth and throat
  54. 7.7 Deposition models
  55. 7.8 Understanding the effect of parameter variations on deposition
  56. 7.9 Respiratory tract deposition
  57. 7.10 Targeting deposition at different regions of the respiratory tract
  58. 7.11 Deposition in diseased lungs
  59. 7.12 Effect of age on deposition
  60. 7.13 Conclusion
  61. Chapter 8. Jet Nebulizers
  62. 8.1 Basic nebulizer operation
  63. 8.2 The governing parameters for primary droplet formation
  64. 8.3 Linear stability of air flowing across water
  65. 8.4 Droplet sizes estimated from linear stability analysis
  66. 8.5 Primary droplet formation
  67. 8.6 Primary droplet breakup due to abrupt aerodynamic loading
  68. 8.7 Primary droplet breakup due to gradual aerodynamic loading
  69. 8.8 Empirical correlations
  70. 8.9 Droplet production by impaction on baffles
  71. 8.10 Degradation of drug due to impaction on baffles
  72. 8.11 Aerodynamic size selection of baffles
  73. 8.12 Cooling and concentration of nebulizer solutions
  74. 8.13 Nebulizer efficiency and output rate
  75. 8.14 Charge on droplets produced by jet nebulization
  76. 8.15 Summary
  77. Chapter 9. Dry Powder Inhalers
  78. 9.1 8asic aspects of dry powder inhalers
  79. 9.2 The origin of adhesion: van der Waals forces
  80. 9.3 van der Waals forces between actual pharmaceutical particles
  81. 9.4 Surface energy: a macroscopic view of adhesion
  82. 9.5 Effect of water capillary condensation on adhesion
  83. 9.6 Electrostatic forces
  84. 9.7 Powder entrainment by shear fluidization
  85. 9.8 Turbulent deaggregation of agglomerates
  86. 9.9 Particle detachment by mechanical acceleration: impaction and vibration
  87. 9.10 Concluding remarks
  88. Chapter 10. Metered Dose Propellant Inhalers
  89. 10.1 Propellant cavitation
  90. 10.2 Fluid dynamics in the expansion chamber and nozzle
  91. 10.3 Post-nozzle droplet breakup due to gradual aerodynamic loading
  92. 10.4 Post-nozzle droplet evaporation
  93. 10.5 Add-on devices
  94. 10.6 Concluding remarks
  95. Index
    by Warren H. Finlay (Author) – 2001

    • Hardcover ‏ : ‎ 320 pages
    • ISBN-10 ‏ : ‎ 0122569717
    • ISBN-13 ‏ : ‎ 978-0122569715
    • Obs.: Livro sem uso, com paginas amareladas e um pouco sujas pelo tempo – capa, contracapa, bordas e paginas integras. sem marcas, grifos, marcações ou qualquer tipo de detalhe que possa interferir na leitura ou pesquisa – Conteudo perfeito

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