Descrição
Motor proteins are molecular machines that convert chemical energy from ATP hydrolysis into mechanical work, which powers cell motility. Over the last ten years, single-molecule techniques and structural studies have led to rapid progess in understanding how these biological motors operate. How do they move? How do they generate force? How much fuel do they consume, and with what efficiency? Mechanics of Motor Proteins and the Cytoskeleton brings these new findings together.
This book is for biology, physics, and engineering students who want to learn about the principles of protein mechanics and how it applies to the morphology and motility of cells. Understanding how motors and the cytoskeleton operate requires mechanical concepts such as force, elasticity, damping, and work. Introductory physics textbooks address these concepts, yet they are concerned primarily with macroscopic systems, whose motions are qualitatively different from the highly damped, diffusive motion of individual molecules.
Contents
1 Introduction 71
2 Cell motility and motor proteins 72
3 Motility assays 73
4 Single-molecules assays 75
5 Atomic structures 77
6 Proteins as machines 78
7 Chemical forces 80
8 Effect of force on chemical equilibria 81
9 Effect of force on the rates of chemical reactions 82
10 Absolute rate theories 85
11 Role of thermal fluctuations in motor reactions 87
12 A mechanochemical model for kinesin 89
13 Conclusions and outlook 92
por
- Capa comum : 380 paginas
- ISBN-10 : 0878933336
- ISBN-13 : 9780878933334
