Descrição
Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry.
CONTENTS.: 1. Retrosynthesis, Stereochemistry, and Conformations2. Acids, Bases and Functional Group Exchange Reactions3. Protecting Groups4. Synthetic Strategies5. Oxidation6. Reduction7. Hydroboration8. Stereocontrol and Ring Formation9. Cd Disconnect Products: Nucleophilic Species That Form Carbon-Carbon Bonds10. Cd Disconnect Products: S and P Carbanions11. Cd Disconnect Products: Nucleophilic Species That Form Carbon-Carbon Bonds: Enolate Anions12. Pericyclic Reactions: The Diels-Alder Reaction13. Pericyclic Reactions: [m+n]-Cycoadditions, Sigmatropic Rearrangements, Electrocyclic and Ene reactions14. Ca Disconnect Products: Electrophilic Carbon-Carbon Bond Forming Reactions15. Carbon Radical Disconnect Products: Formation of Carbon-Carbon Bonds Via Radicals and Carbenes 16. Metal-Mediated Reactions17. Process Chemistry and Combinatorial Chemistry
Author: Michael Smith – 2017
- Hardcover : 1083 pages
- ISBN-10 : 0128007206
- ISBN-13 : 9780128007204
