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Section 1: The Scientific Basis of Rheumatic Disease
1. Epidemiologic concepts and the classification of rheumatic and musculoskeletal conditions
2. Principles of clinical outcome assessment
3. Principles of health economics and application to rheumatic disorders
4. The synovium
5. The articular cartilage
6. Bone structure and function
7. Tendons and ligaments
8. Connective tissue responses to mechanical stresses
9. Biomechanics of peripheral joints
10. Biomechanics of the spine
11. Principles of genetic epidemiology
12. Principles and techniques in molecular biology
13. Cytokines
14. Signal transduction in immune cells
15. The principles of adaptive immunity
16. Principles of innate immunity
17. Systems biology
18. Epigenetics in Rheumatology
19. The microbiome in rheumatic diseases
20. Tissue destruction and repair
21. Principles of tissue engineering and cell- and gene-based therapy
22. Osteoimmunology
23. Inflammation and its mediators
24. Scientific basis of pain
25. Effects of the neuroendocrine system on development and function of the immune system
26. Interpreting the medical literature for the rheumatologist; study design and levels of evidence
27. Ethics in clinical trials
Section 2: Clinical Basis of Rheumatic Disease
28. History and physical examination
29. Pattern recognition in arthritis
30. Role of laboratory tests in rheumatic disorders
31. Synovial fluid analysis
32. Minimally invasive procedures
33. Skin in rheumatic disease
34. The eye in rheumatic disease
35. The heart in rheumatic disease
36. The lung in rheumatic disease
37. Gastrointestinal tract and rheumatic disease
38. The kidney and rheumatic disease
39. The nervous system in rheumatic disease
Section 3: Evaluation: Imaging Techniques
40. Conventional radiography and computed tomography
41. Functional magnetic resonance imaging
42. Musculoskeletal ultrasound
43. Bone scintigraphy and positron emission tomography
44. DXA and measurement of bone
45. Use of imaging as an outcome measure in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis in clinical trials
Section 4: Principles of Management
46. Arthritis patient education, health promotion, and team approaches to management
47. Principles of rehabilitation: physical and occupational therapy
48a. Complementary and alternative medicine
48b. Placebos, Caring and Healing in Rheumatology
49. Drug Development
50. Non-pharmacologic pain management
51. Pharmacogenomics in rheumatology
52. Principles of opioid treatment of chronic musculoskeletal pain
53. Non-steroidal anti-inflammatory drugs
54. Systemic glucocorticoids in rheumatology
55. Antimalarials, parenteral gold, sulfasalazine, and other nonimmunosuppressive DMARDS
56. Methotrexate
57. Leflunomide
58. Immunosuppressives: Cyclosporine, Cyclophosphamide, Azathioprine, Mycophenolate mofetil
59. T-cell costimulation and other directed therapies
60. B-Cell Therapy
61. Cytokine neutralizers: IL-1 inhibitors
62. IL-6 Inhibition
63. Tumor necrosis factor blocking therapies
64. Kinase inhibition – a new therapeutic principle in rheumatology
65. Emerging therapeutic targets: GM-CSF, IL-17and IL-23
66. Biosimilars in Rheumatology
67. Infections and biologic therapy in rheumatoid arthritis
68. Drugs and pregnancy
69. Aspiration and injection of joints and periarticular tissues and intralesional therapy
70. Perioperative care of the rheumatic disease patient
Section 5: Regional and Widespread Pain
71. Neck pain
72. Lumbar spine disorders
73. The shoulder
74. The elbow
75. The wrist and hand
76. The hip
77. The knee
78. The ankle and foot
79. The temporomandibular joint
80. Fibromyalgia and related syndrome
81. Entrapment neuropathies and compartment syndromes
82. Complex regional pain syndrome (reflex sympathetic dystrophy)
Section 6: Rheumatoid Arthritis and Other Synovial Disorders
83. Classification and epidemiology of rheumatoid arthritis
84. Preclinical features of rheumatoid arthritis
85. Clinical features of rheumatoid arthritis
86. Extra-articular features of rheumatoid arthritis and systemic involvement
87. Adult-onset Stills disease
88. Imaging of rheumatoid arthritis
89. The contribution of genetic factors to rheumatoid arthritis
90. Animal models of arthritis
91. Autoantibodies in rheumatoid arthritis
92. Cellular immunity in rheumatoid arthritis
93. Angiogenesis and vasculogenesis in rheumatoid arthritis
94. The rheumatoid joint: synovitis and tissue destruction
95. Evaluation and management of early inflammatory polyarthritis
96. Evaluation and outcomes of patients with rheumatoid arthritis
97. Management of rheumatoid arthritis: synovitis
98. Multidisciplinary approach to rheumatoid arthritis
Section 7: Pediatric Rheumatology
99a. Evaluation of musculoskeletal complaints in children: Clinical Evaluation
99b. Evaluation of musculoskeletal complaints in children: Non-inflammatory musculoskeletal disorders
100. Classification and epidemiology of juvenile idiopathic arthritis
101. Clinical Features of juvenile idiopathic arthritis
102. Etiology and pathogenesis of juvenile idiopathic arthritis
103. Management of juvenile idiopathic arthritis
104. The juvenile-onset spondyloarthropathies
105. Connective tissues diseases in children
106. Rehabilitation and psychosocial issues in juvenile idiopathic arthritis
Section 8: Infection-Related Rheumatic Diseases
107. Infectious Arthritis I: Bacterial Arthritis
108. Infectious Arthritis II: Mycobacterium, brucella, fungal, and parasites
109. Lyme disease
110. Rheumatologic aspects of viral infections
111. Acute rheumatic fever
112. Reactive arthritis
Section 9: Spondyloarthropathies
113. Classification and epidemiology of spondyloarthritis
114. Clinical features of axial spondylarthritis
115. Etiology, pathogenesis, and pathophysiology of ankylosing spondylitis
116. Genetics of axial spondyloarthritis
117. Imaging of spondyloarthritis
118. Management of ankylosing spondylitis/axial spondyloarthritis
119. Classification and epidemiology of psoriatic arthritis
120. Clinical features of psoriatic arthritis
121. Etiology and pathogenesis of psoriatic arthritis
122. Management of psoriatic arthritis
123. Enthesopathies
Section 10: Connective Tissue Disorders
124. Epidemiology and classification of systemic lupus erythematosus
125. Preclinical features of lupus
126. Clinical features of systemic lupus erythematosus
127. Genetics of lupus
128. Immunopathology of systemic lupus erythematosus
129. Animal models of lupus
130. Autoantibodies in systemic lupus erythematosus
131. Pathogenesis of lupus
132. Drug-induced lupus
133. Assessing disease activity and outcome in systemic lupus erythematosus
134. The management of non-renal/non-CNS lupus
135. Treatment of Neuropsychiatric Lupus
136. Systemic lupus erythematosus: treatment-renal involvement
137. Systemic lupus erythematosus in the pregnant patient and neonatal lupus
138. Sjögren syndrome
139. Antiphospholipid syndrome: overview of pathogensis, diagnosis, and management
140. Classification and epidemiology of scleroderma
141. Assessing disease activity and outcome in scleroderma
142. Clinical features of systemic sclerosis
143. Etiology and pathogenesis of systemic sclerosis
144. Management of systemic sclerosis
145. Pulmonary management of systemic sclerosis
146. Raynauds phenomonen
147. Localized scleroderma and scleroderma-like syndromes
148. Clinical features, classification, and epidemiology of inflammatory muscle disease
149. Inflammatory muscle disease-etiology and pathogenesis (myositis)
150. Management of inflammatory muscle disease
151. Metabolic, drug-induced, and other non-inflammatory myopathies
152. Overlap syndromes
Section 11: The Vasculitides
153. Classification and epidemiology of vasculitis
154. Biology and immunopathogenesis of vasculitis
155. Polyarteritis nodosa and Cogans Syndrome
156. Polymyalgia rheumatica and giant cell arteritis
157. ANCA-associated vasculitis
158. Takayasus arteritis
159. Behçets syndrome
160. Kawasaki disease
161. Henoch schoenlein purpura/Immunoglobulin-A vasculitis
162. Cutaneous vasculitis and panniculitis
163. Cryoglobulinemia
164. Primary angiitis of the central nervous system
Section 12: Other Systemic Illnesses
165. Monogenic Autoinflammatory Diseases
166. Sarcoidosis
167. Relapsing polychondritis
168. Amyloidosis
169. Digital clubbing and hypertrophic osteoarthropathy
170. Miscellaneous arthropathies
Section 13: Osteoarthritis and Related Disorders
171. Osteoarthritis: epidemiology and classification
172. Local and systemic risk factors for incidence and progression of osteoarthritis
173. Clinical features of osteoarthritis
174. Animal models of osteoarthritis
175. Pathogenesis and pathology of osteoarthritis
176. Genetics of osteoarthritis
177. Imaging of osteoarthritis
178. Assessment of the patient with osteoarthritis and measurement of outcomes
179. Preclinical osteoarthritis
180. Assessment of imaging outcomes in osteoarthritis
181. Management of osteoarthritis
182. Diffuse idiopathic skeletal hyperostosis
183. Neuropathic arthropathy
184. Osteonecrosis
185. Rare Osteoarthritis: Ochronosis and Kashin–Beck disease
Section 14: Crystal-Related Arthropathies
186. Epidemiology of Gout
187. Etiology and pathogenesis of gout
188. Clinical gout
189. The management of gout and hyperuricemia
190. Calcium pyrophosphate crystal-associated arthropathy
191. Basic calcium phosphate crystal deposition disease
192. Other crystal-related arthropathies
Section 15: Endocrine and Hemoglobin-Related Arthritis and Storage Diseases
193. Rheumatoid manifestations of endocrine and lipid disease
194. Hemophilia and von Willebrand disease
195. Joint and bone lesions in hemoglobinopathies
196. Hemochromatosis
Section 16: Metabolic Bone Disease
197. Epidemiology and classification of osteoporosis
198. Osteoporosis: clinical features of osteoporosis
199. Pathogenesis of osteoporosis
200. Biochemical markers in bone disease
201. Management of osteoporosis
202. Glucocorticoid-induced osteoporosis
203. Osteomalacia and rickets
204. Primary hyperparathyroidism: rheumatologic manifestations and bone disease
205. Renal osteodystrophy
206. Pagets disease of bone
Section 17: Heritable Disease and Tumors of Bone and Connective Tissue
207. Gauchers disease
208. Mucopolysaccharidoses
209. Heritable connective tissue disorders
210. Hypermobility syndrome
211. Skeletal dysplasias
212. Bone tumors

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