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Feliz Natal

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Feliz Natal e Próspero 2010

Chemistry and Molecular Aspects of Drug Design and Action

Chemistry and Molecular Aspects of Drug Design and Action Autor: Rekka
Editora: CRC - 2008
ISBN: 0849390060
Área: Ciências Farmacêuticas
N. Páginas: 384 pgs.

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Prazo de entrega:
Livros nacionais: 30 dias úteis.
Livros importados: 60 dias úteis.

Table of Contents
Introduction: Rational Drug Design—Two Examples Based on Pathobiochemistry, E.A. Rekka, A.P. Kourounakis, and P.N. Kourounakis
Part I: Chemical, Biochemical, and Biological Aspects of Pathophysiological Conditions
Inflammatory Mechanisms in Alzheimer’s Disease and other Neurodegenerative Disorders, J. Rogers, T. Beach, R. Li, Z. Liang, L.F. Lue, A. Roher, M. Sabbagh, Y. Shen, R. Strohmeyer, and D. Walker
Treatment Development Strategies for Alzheimer’s Disease, E. Wülfert
Lipoprotein-Associated Phospholipase A2 as a New Prognostic Factor for Coronary Artery Disease, A. Tselpis
Protein Modifications by Nitric Oxide and Reactive Nitrogen Species, H. Ischiropoulos
Part II: Classical Medicinal Chemistry
Design, Synthesis, and Pharmacological Evaluation of High Affinity and Selectivity Sigma-1 and Sigma-2 Receptor Ligands, J.H. Poupaert
Synthesis of Biologically Active Taxoids, K.C. Nicolaou and R.K. Guy
From the Molecular Pharmacology to the Medicinal Chemistry of Cannabinoids, D.M. Lambert
New Inhibitors of DNA Topoisomerase in the Treatment of Experimental Malignancies, C. Atassi
Treatment of Psoriasis with Anthrones – Biochemical Aspects, W. Wiegrebe and K. Müller
An Appraisal of Fomocaines, Current Situation and Outlook, H. Oelschläger and A. Seeling
Ligands for the GABA Recognition Site at the GABAA Receptor: Structure-Activity Studies, B. Frǿlund, U. Kristiansen, P. Krogsgaard-Larsen, and T. Liljefors
Part III: Drug Design, Chemical and Molecular Aspects of Drug Action
Discovery of Potent and Selective Inhibitors of Human Aldosterone Synthase (CYP11B2)—A New Target for the Treatment of Congestive Heart Failure and Myocardial Fibrosis: A Review, R.W. Hartmann, U. Müeller-Vieira, S. Ulmschneider, and M. Voets
A New Class of Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI’s) with Great Potential for the Treatment of Human Immunodeficiency Virus Type 1 (HIV-1) Infections, E. De Clercq, A. Karlsson, and J. Balzarini
Histamine H3-Receptor Agonists and Antagonists: Chemical, Pharmacological, and Clinical Aspects, H. Stark and W. Schunack
Anti-Inflammatory Actions of Flavonoids and Structural Requirements, T. Theoharides
Molecular Mechanisms of H2O2-Induced DNA Damage: The Action of Desferrioxamine, M. Tenopoulou, P.T. Doulias, and D. Galaris
LNA (Locked Nucleic Acid) and Functionalized LNA: Towards Efficient Gene Targeting, J. Wengel
Part IV: Drug Xenobiotic Metabolism
The Effect of Diet on Drug Metabolism, K.J. Netter
Cytochromes P450 in the Metabolism and Bioactivation of Chemicals, C. Ioannides
In Vitro Methods to Measure Drug Metabolism and Metabolic Interactions in Drug Discovery and Development, O. Pelkonen, M. Turpeinen, J. Uusitalo, P. Taavitsainen, and H. Raunio
Part V: Physical Organic and Theoretical Medicinal Chemistry
How to Probe the Sites of Action of Drug Molecules, A. Makriyannis and F. Bitter
Lipophicility as a Descriptor of Molecular Properties in Drug Design, B. Testa, G. Caron, P.A. Carrupt, A. Pagliava, and G. Steyaert
Drug Membrane Interaction and the Importance for Drug Transport, Distribution, Accumulation, Efficacy, and Resistance, J.K. Seydel, E.A. Coates, K. Visser, and M. Wiese
Structure-Based and Computer-Aided Drug Design, H. Kubinyi
Physiochemical Profiling in Early Drug Discovery: New Challenges at the Age of High Throughput Screen and Combinational Chemistry, B. Faller

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